Innovative Solutions for Automated Imaging

MetaSystems has been developing and producing system software for automated microscopy since 1986. Today, users in more than 103 countries rely on the laboratory solutions by MetaSystems.

In addition to generating the highest quality images, our modern approaches include an advanced workflow management that grows with your requirements.

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Brain Tissue Microarrays (TMA)

A TMA consists of an array of cylindrical tissue cores extracted from different paraffin-embedded tissue ‘donor’ blocks, which are subsequently punched into a ‘recipient’ paraffin block. In diagnostic applications, there has been concern as to whether 0.6 mm or 1 mm cores are accurately representative of a tissue cross-section containing heterogeneous tumour cell populations. [...], commercially available systems such as the VSlide scanner (MetaSystems) coupled with MetaMorph software (Molecular Devices) can streamline image acquisition and analysis of cores. This coupling of scanner and software enables high-throughput processing of immunolabelled TMA sections, and thus avoids the effects of inter- and intra-observer subjectivity that is intrinsic to manual microscope analysis. [...] We demonstrate the use of VSlide scanner [...] coupled with [...] image analysis software to analyse tissue microarrays in a cost effective and user friendly manner. [...] VSlide offers a customisable and user friendly tissue microarrayer tool enabling easy TMA acquisition by non-experts. [...], automated image analysis based methods provide objective, consistent and reproducible pathological assessment.

Cited From: J Neurosci Methods (2015) Read more...
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